The Study of Effect of Levofloxacin on Disorders of Female Hormones in Rats

Introduction: Levofloxacin is one of the antibiotics with wide treatment application which is often applied for treating infections of genitourinary system and lower respiratory tract. Noting that most antibiotics can affect the structure of ovary tissue, we have launched research into the effect of Levofloxacin on hormone disorder resulting from tissue damage. Methods: In this survey, 40 Wistar rats with the weight of 20±25 gr and approximate age of 8 weeks were used. They were divided into 4 groups with 10 rats. The study groups were tube fed with 200, 500 and 750 mml of Levofloxacin for each kg of weight. The control group didn’t receive anything. Duration of the survey lasted 22 days. The rats were under 12 hours light-dark cycle, 24.7-26.4 temperature and 55-66% humidity. After the termination of this term, the blood sample was taken from their hearts and the serums were sent to clinical laboratory So as the level of hormone to be measured. Results: Titration of level of LH, FSH, PROG hormones revealed that there was significant decrease of the level of hormone after consuming antibiotics in comparison with that of control group. Conclusion: Levofloxacin antibiotic is one of the factors which can destroy ovary tissue, and gives rise to hormone disorder. This point should be considered in case of administration of drugs.